The Red Wine Diet

The Red Wine Diet

This diet is the single best way to lose weight if you'd rather not spend every spare minute on the treadmill and eating carrots and broth. You can lose the same amount of weight or MORE just by following the easy instructions in this ebook from Art Mcdermott, Certified Nutritionist and Strength Coach. Believe it or not, red wine is not a guilt pleasure. It is a very good and helpful part of your diet. The antioxidants in red wine alone can help you a lot in your quest to stay healthy! You don't have to just eat kale and carrots to lose weight Why not have a little something that tastes good as well? You will learn a lot in this ebook, including why alcohol is not your enemy in weight loss, the real health benefits of red wine that no one talks about, and addictive foods to avoid. Don't just avoid foods Get some red wine too! Read more...

The Red Wine Diet Summary


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Nutritional Antioxidants And Polyphenolic Flavonoids

We have performed in vitro and ex vivo studies in humans and in the atherosclerotic E0 mouse, and in a cell-free system, which demonstrated that the licorice root extract and its purified isoflavane glabridin protected LDL against macrophage-induced oxidation.31-35 Flavonols and their glycosides are effective antioxidants against 2,2'-azobis 2-amidino-propane dihydrochloride (AAPH- free-radical generator) and copper ion-induced LDL oxidation. The flavonols bearing the orthodihy-droxyl groups possess significantly higher antioxidative activity than those bearing no such functionalities. The flavonol glycosides are less effective in this respect.36 Red wine and its flavonol quercetin were shown to inhibit LDL oxidation in both water and lipid-soluble free-radical-generating systems.37,38 We have previously shown that preparation of white wine from whole squeezed grapes in the presence of 18 alcohol remarkably increased the extraction of grape skin polyphenols into the produced white...

Nuclear Magnetic Resonance in Stilbene and Wine Research

Many NMR-based metabolomics studies on grapevine have been reported however, they have mainly been used for the classification of wine products based on their polyphenolic composition. For example, NMR coupled with multivariate statistics has proved to be a suitable method for studying the effect of environmental vineyard conditions on the chemical composition of grapes and their wines 123 or for the differentiation of wines based on grape varieties 123 . A similar approach was used recently for studying the in vitro bioconversion of polyphenols from red wine and grape juice by human intestinal microbiota 124 .

Flavonoids And Cardiovascular Diseases

Flavonoids compose the largest and the most studied group of plant phenolics. Over 4000 different flavonoids have been identified to date. Flavonoids are grouped into anthocyanins and anthoxanthins. Anthocyanins are glycosides of anthocyanidin, and they are the most important group of water-soluble plant pigments, responsible for the red, blue, and purple colors of flowers and fruits. Anthoxanthins are colorless or colored white-to-yellow, and include flavonols, flavanols, flavones, flavans, and isoflavones. Flavonoids are powerful antioxidants, and their activity is related to their chemical structure.118,119 Plant flavonoids can act as potent inhibitors of LDL oxidation,120,121 or of macrophage oxidation.122 Dietary consumption of flavonoids was shown to be inversely related to morbidity and mortality from coronary heart disease.123 Moreover, an inverse association between flavonoid intake and subsequent occurrence of ischemic heart disease, or cerebrovascular disease, was...

Flavonoids have multiple functions in plants

Many flavonoids are antioxidants in acting as radical scavengers for reactive oxygen species (ROS), thus preventing the peroxidation of lipids. As constituents of nutrients, they are assumed to be protectants against cardiovascular diseases and cancer. For this reason, nutrients containing flavonoids (e.g., green tea, soy sauce, and red wine) have been regarded as beneficial for health.

Pomegranates 561 Chemistry

Total antioxidants 100g vs. 8.23 mmol antioxidants 100 g in wild bilberry (Vaccinium myrtillus), 2.42 mmol antioxidants 100 g for grapes (Vitis vinifera) and 0.34 mmol antioxidants 100 g for tomatoes (Lycopersicon esculentum).17 In North America, most pomegranate consumption occurs from drinking pomegranate juice. The total polyphenol concentration in pomegranate juice is higher than that of green tea and red wine, giving pomegranate juice a threefold higher antioxidant capacity.15 Commercial pomegranate juice contains over 20 different polyphenols anthocyanins (delphinidin, cyanidin, and pelargonidin and their glycosides), hydrolyzable tannins (ellagitannins, gallotannins, punicalagin, punicalin), and phenolics (ellagic acid, gallic acid) 1516 other than those named, most have not yet been identified. Other components of note are water soluble poly- and oligo-saccharides (containing mainly glucose, sucrose, xylose, and galactose compounds), organic acids (citric, malic), and seed oil...

Reference For Medicinal Plant Pomegranate

Krueger, C.G., Vestling, M.M., and Reed, J.D., Matrix-assisted laser desorption ion-ization time-of-flight mass spectrometry of anthocyanin-polyflavan-3-ol oligomers in cranberry fruit (Vaccinium macrocarpon, Ait.) and spray dried cranberry juice, in Red wine color revealing the mysteries, ACS Symposium Series, eds. A.L. Waterhouse and J.A. Kennedy, vol. 886, American Chemical Society, Washington, D.C., 2004, 232. Reed, J.D., Krueger, C.G., and Vestling, M.M., MALDI-TOF mass spectrometry of oligomeric food polyphenols, Phytochemistry, 66, 2248, 2005. Porter, M.L. et al., Cranberry proanthocyanidins associate with low-density lipoprotein and inhibit in vitro Cu2+-induced oxidation, J. Sci. Food and Agric., 81, 1306, 2001.

Role Of Pomegranate Fruit Phytochemicals In Bioactivity

Linoleic acid, then measuring P-carotene consumption as a result of its oxidation in the reaction mixture.5152 Both fermented products demonstrated moderate activity, less than the commercial synthetic antioxidant butylated hydroxyl anisole, and more than red wine. PFJ was not active as a cyclooxygenase inhibitor and only weakly inhibited lipoxygenase, while PCPSO revealed weak activity against cyclooxygenase and a strong inhibitory effect on lipoxygenase. As previously discussed, the major fatty-acid constituent in PCPSO is punicic acid, which is found in pomegranate seed oil (> 60 of the total oil). The antioxidant activity in PJ that was freshly prepared from arils was compared to that in commercial PJ extracted from whole pomegranate, red wine, and green tea infusion.32 Antioxidant activity was determined using four different assays, three of them based on evaluations of the free-radical scavenging capacity of the juice (ABTS, DPPH, N,N-dimethyl-p-phenylenediamine-DMPD), and the...

Pomegranate Vascular Remodeling

The pomegranate's medicinal qualities have been known for thousands of years. References in the Bible and Roman mythology mention the tree's unique healing powers, and some Middle Eastern, Asian, and South American people still chew its bark, petals, and peel to treat conditions as diverse as dysentery and diseases of the mouth and gums.1 Modern research has shown that the pomegranate contains polyphenols and anthocyanidins that are powerful free-radical scavengers and are more effective against disease than are those in red wine and green tea.2 It is widely used in traditional medicine to cure inflammation, diabetes, cardiac disease, AIDS, ischemia, and cancer (Figure 6.1). On this basis, the possible anticarcinogenic effects of the pomegranate have been further explored. For example, the application of pomegranate extract to the skin of mice before they were exposed to a carcinogenic agent was shown to inhibit the appearance of erythemas and hyperplasia and the activity of...


Quercitin is a bioflavonoid frequently used to treat allergies because of its antihistamine, antiinflammatory, and antioxidant effects. It is found in foods such as berries, brassica vegetables, apples, green tea (Camellia sinensis), onions, and red wine. Studies have demonstrated that quercitin inhibits the release of histamine from mast cells and basophils.50 (Histamine is a chemical mediator responsible for allergy symptoms, such as constriction in the lungs, congestion, and sneezing.) Absorption of quercitin is variable and may be improved by combining it with papain or bromelain.

Concluding Remarks

Stilbenes are stress-induced phenylpropanoids which result from the condensation of p-coumaroyl-CoA or cinnamoyl-CoA with malonyl-CoA by the action of stilbene synthase. In grapevine, resveratrol is a low molecular weight stilbene acting as a phytoalexin (Bavaresco et al. 2009). Its synthesis is elicited in leaves, berries and cell suspensions in response to biotic, abiotic and nutritional stress. N supply decreased resveratrol in leaves and berries (Bavaresco et al. 2001). However, the effects of sulfur availability on phenylpropanoid compounds, including anthocyanins and resveratrol, have not been elucidated. These compounds have important roles in the resistance of grapevine to biotic and abiotic stresses and can confer antioxidant properties to red wine therefore the cross talk between sulfur and phenylpropanoid metabolism is an important research avenue to investigate.


Most of the studies on anthocyanin bioavailability in humans have been undertaken by giving the volunteers berries (whole or freeze-dried), berry extracts, or berry juices. Anthocyanin concentrations measured in plasma were usually very low (about 10 to 50 nmol L). The mean time to reach Cmax for plasma was 1.5 h (range 0.75 to 4 h) and 2.5 h for urine. Most studies reported low relative urinary excretions, ranging from 0.004 to 0.1 of the intake, although Lapidot et al.29 and Felgines et al.30 measured higher levels of anthocyanin excretion (up to 5 ) after red wine or strawberry consumption. The time course of absorption was consistent with absorption in the stomach, as described for animals.31,32 Therefore, it is noticeable that anthocyanins are usually very rapidly absorbed and eliminated. However, they are absorbed with rather poor efficiency.

Wise Dietary Choices

A small randomized, crossover, nonblinded study in patients with Alzheimer's disease examined the effect of increasing the amount of carbohydrates with meals, without changing the protein intake. The results showed poorer memory, and increased aberrant motor behavior with the increased carbohydrate intake.7 Research has also examined the Mediterranean diet and the risk of Alzheimer's disease. The results indicate that higher adherence to the Mediterranean diet was associated with lower risk for Alzheimer's disease, and the association does not seem to be mediated by vascular comorbidity.8 In addition, a literature review showed that high energy intake of monounsaturated fatty acids appeared to be associated with a high level of protection against age-related cognitive decline, fish consumption and cereals are found to reduce the prevalence of Alzheimer's disease, and the relative risk of dementia was lower in subjects who drank three or four glasses of red wine each day compared with...

Blood Lipids

Several lines of evidence support the concept that raising HDL may provide substantial atheroprotective benefit. A rise in serum HDL by 1 mg dL has been proposed to reduce the risk of CVD by 2 to 3 . Current approaches to increase HDL levels in plasma include dietary intervention.77-79 Several studies indicate that light to moderate alcohol consumption, including red wine, is associated with an increase in serum HDL levels,8081 along with a low prevalence of coronary heart disease.

Paraoxonase 1 PON1

The increased resistance of LDL and of HDL to oxidation after PJ administration to healthy subjects or to patients with CAS could have also resulted from increased serum HDL-associated paraoxonase activity. Indeed, a significant 18 increase in serum paraoxonase (PON 1) activity was monitored in healthy subjects after PJ consumption for a period of 2 weeks.145 In CAS patients, serum paraoxonase 1 (measured as arylesterase activity) significantly increased by 11 , 42 , 49 , and 83 after 3, 6, 9, and 12 months of PJ consumption, respectively.148 Similar to the results in humans, a significant 43 increase in serum paraoxonase activity was also observed in E0 mice after PJ consumption for a period of 2 months, in comparison to serum paraoxonase activity observed in the placebo-treated mice.146 The increase in serum paraoxonase activity may be a direct effect of PJ, as well as an effect secondary to PJ-mediated reduction in lipid peroxides. It was previously demonstrated that paraoxonase is...


Vitis vinifera is commonly known as the classic wine grape. Grapes and theirjuices are high in flavonoids, which are believed to give red wine its cardiovascular protective qualities. Research has shown that grape products, such as grapejuice and red wine, increase NO release from platelets, and decrease platelet aggregation and superoxide production.55 More specifically, research on a constituent of grape skins and seeds known as resveratrol has produced effects on NO. Resveratrol has been demonstrated to have estrogen-like activity and antioxidant, antiplatelet, anti-inflammatory, and anticarcinogenic properties. Studies indicate that resveratrol up-regulates the gene expression of endothelial NOS with a resulting increase in NO levels.56

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