Subacute Phase of Brain Injury

During the subacute phase (hours after ischemia), the migration of leukocytes into the compromised brain tissue (Section 5.5.1) amplifies inflammatory signaling cascades.24,34-36 Inflammatory mediators and proteases such as the matrix metallopro-teinases (MMP-2 and -9) and interleukins (IL-1) are thought to mediate damage during the inflammatory phase of ischemia.24,37,38 Indeed, inhibitors of MMP-9 are neuroprotective in experimental stroke, and MMP-9 knockout mice show much smaller ischemic lesions.38 Proinflammatory genes such as COX-2 and IL-1P are up-regulated in the ischemic brain;35,36 COX-2 activity has been implicated in the pathogenesis of neuronal cell death in ischemia and other diseases, but the mechanism by which COX-2 exacerbates cell death is unknown.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment