Pomegranate Vascular Remodeling

The pomegranate's medicinal qualities have been known for thousands of years. References in the Bible and Roman mythology mention the tree's unique healing powers, and some Middle Eastern, Asian, and South American people still chew its bark, petals, and peel to treat conditions as diverse as dysentery and diseases of the mouth and gums.1 Modern research has shown that the pomegranate contains polyphenols and anthocyanidins that are powerful free-radical scavengers and are more effective...

Risk Factors For Cardiovascular Diseases

There are several factors that increase the risk of developing CVD. These risk factors may be nonmodifiable, such as a family history of cardiovascular disease, race (black, aborginal), and age.1,3,19 However, many of the risk factors for heart attack and stroke are indeed modifiable with changes in behavior, drugs, or diet. Eighty percent of the Canadian population has at least one modifiable risk factor for cardiovascular disease.3 Smoking is the single most important cause of preventable...

Role Of Pomegranate Fruit Phytochemicals In Bioactivity

The scope of this section is to review the current knowledge on the bioactivities of phytochemicals found in the pomegranate fruit. The emphasis is placed on those studies relating the observed bioactivities (in commercial or freshly prepared juice, peels, and seeds, with or without prefermentation) to specific phytochemical constituents of the pomegranate, even where such linkages have not yet been proven. The major in vitro and in vivo bioactivities evaluated to date have been the antioxidant...

Hypertension

Hypertension is a major risk factor for the development of atherosclerosis. In hypertensive patients with elevated plasma renin activity, increased incidence of myocar-dial infarction by fivefold has been demonstrated.9 In hypertensive patients, serum concentrations of angiotensin II (Ang-II), an active vasoconstrictor produced by the renin-angiotensin-aldosterone system (RAS), are elevated.10 Ang-II was implicated in acceleration of atherosclerosis11,12 not only by causing hypertension, but...

Reference For Medicinal Plant Pomegranate

Tanaka, T., Nonaka, G., and Nishioka, I., Tannins and related compounds. XL. Revision of the structures of punicalin and punicalagin, and isolation and characterization of 2-O-galloylpunicalin from the bark of Punica granatum L., Chem. Pharm. Bull., 34, 650, 1986. 2. Tanaka, T., Nonaka, G., and Nishioka, I., Tannins and related compounds. XLI. Isolation and characterization of novel ellagitannins, punicacorteins A, B, C and D, and punigluconin from the bark of Punica granatum L, Chem. Pharm....

Pomegranate Phytochemicals

The different types of phytochemicals that have been identified from various parts of the pomegranate tree and from pomegranate fruits and seeds are listed in Table 1.1, items 1 to 31, and Figure 1.1a through Figure 1.1m show their chemical structures. The major class of pomegranate phytochemicals is the polyphenols (phenolic rings bearing multiple hydroxyl groups) that predominate in the fruit. Pomegranate polyphenols include flavonoids (flavonols, flavanols, and anthocyanins), condensed...

Cardiovascular Disease Statistics

The 2002 World Report on Violence and Health published by the WHO (Geneva)4 lists ischemic heart disease as the top cause of death among its member states, accounting for 12.4 of all deaths in 2000.45 Cerebrovascular disease, or stroke, accounted for 9.2 of deaths.4 In Canada, cardiovascular disease accounted for 74,626 Canadian deaths (32 of all male deaths and 34 of all female deaths) in 2002.23 In the U.S.119 and Canada,23 stroke is the third leading cause of death after heart disease and...