Relationship to Tissue and Organ Development

Over the past two decades, it has become clear that Tyr phosphorylation plays a pivotal role in a variety of important signaling pathways in multicellular organisms. It is deeply involved in the development of multicellular organisms, including higher eukaryotes such as mammals as well as lower eukaryotes such as sponge and hydra [8] and even prokaryotes such as M. xanthus [9]. In animals, PTKs and PTPs play important roles in the regulation of cell growth and differentiation [10]. Because unregulated Tyr phosphorylation signaling causes a breakdown in the normal regulation of cell proliferation and motility, leading to diseases including cancer, this signaling pathways is now a major focus of biomedical research.

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