Computational Proteomics

8 BIOINFORMATICS IN GEL-BASED PROTEOMICS 107

Âsa M. Wheelock and Craig E. Wheelock

8.1 Introduction and Brief Bibliographic Review 107

8.2 Methodology and Strategy 112

8.3 Experimental Results and Applications 120

8.4 Conclusions 122

8.5 Five-Year Viewpoint 123 References 124

9 BIOINFORMATICS IN MS-BASED PROTEOMICS 127

Jacques Colinge

9.1 Introduction 127

9.2 Database Searching 128

9.3 Peptide De Novo Sequencing 135

9.4 Conclusions and Five-Year Viewpoint 138 References 139

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