Alois Schweighofer • Irute Meskiene (K)
Max F. Perutz Laboratories, University of Vienna, Dr. Bohrgasse 9, 1030 Vienna, Austria [email protected]
Abstract Intracellular signalling systems communicate the inputs perceived at the cell membranes to the nucleus to regulate cellular functions in developmental and stress responses. Pivotal to these transmissions are the reversible protein phosphorylations performed by opposing actions of protein kinases and protein phosphatases. Phospho-rylation by protein kinases is an essential posttranslational modification mechanism for the majority of cellular proteins and can influence protein activity, localization and stability. The significance of protein phosphorylation by kinases is already established in Arabidopsis; but the importance of de-phosphorylation by phosphatases has not been studied equally intensively. Nevertheless, recent characterization of Arabidopsis protein phosphatase mutants and identification of interacting proteins/substrates highlights the important role of protein phosphatases in the pathways regulating stress, hormonal signalling, metabolism, cell cycle and plant growth. In this review we will focus principally on the involvement of plant protein phosphatases of PTP and PP2C-types in these processes.
Was this article helpful?