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Denatured protein resulting from heat shock: HSP 70 and HSP 90 are limiting and are released from the complex.

¡"active

Heat stress

Dissociation from DNA element

HSP 70 excess

¡"active

Heat stress

Dissociation from DNA element

HSP 70 excess

Fig. 1.3.4. The heat shock factor (HSF) cycle. (After Nover and Hohfeld 1996)

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