Detoxification Of Electrophilic Xenobiotics

Various electrophilic xenobiotics, i.e. compounds with centres of low electron density that can accept an electron pair to form a covalent bond, exhibit the tendency to react spontaneously with nucleophilic sites (i.e. centres of electron richness, non-bonded pairs of electrons or bonds) of bio-molecules. Thus, electrophilic xenobiotics may be highly dangerous to the cell, because they are able to bind to proteins and genetic material, i.e. DNA and RNA and thereby disturb metabolic networks....