been linked to cataracts in a number of studies.21,22 Older patients who take riboflavin and niacin daily may be partially protected against cataract development.22 Quercitin, a molecule belonging to the water-soluble bioflavonoids, has been shown to potentiate the vitamin C activity23 as well as block enzymatic activity (aldose reductase) in the sorbitol pathway.23 This influence on the polyol pathway could prove to be very significant in managing cataract-related dysfunction in patients with diabetes who have altered sorbitol metabolism.
Numerous animal models have demonstrated efficacy of alpha-lipoic acid supplementation against cataracts. Alpha-lipoic acid, a potent antioxidant, also regenerates endogenous antioxidants, such as vitamin E, vitamin C, and glutathione. Studies show that oral lipoic acid supplementation delayed development and progression of cataracts in rats with experimentally induced diabetes.24 Another study treated newborn rats with buthionine sulfoximine to induce cataract formation. Treatment with R- and racemic alpha-lipoate decreased cataract formation from 100% buthionine sulfoximine to 55% with buthionine sulfoximine and R-alpha-lipoic acid and to 40% with buthionine sulfoximine and rac-alpha-lipoic acid. Buthionine sulfoximine treatment decreased the lens antioxidants showing a decrease in glutathione by 45%, ascorbate by 62%, and vitamin E by 23%, but were maintained at 84%-97% of control levels when R-alpha-lipoic acid or rac-alpha-lipoic acid were administered with buthionine sulfox-
Although the benefits of rutin or other bioflavonoids for people with glaucoma have been recognized, they have not been investigated thoroughly.
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Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...