Proteolytic Enzymes

Proteolytic enzymes have analgesic effects in addition to their well-recognized antiinflammatory and antiedemic properties. Enzyme-derived analgesia is based on inhibition of the inflammatory cascade as well as exerting a direct influence on nociceptors.3 Bromelain (pineapple; Ananas comosus) is used orally to treat acute swelling and inflammation following trauma. Bromelain is a grouping of proteolytic enzymes obtained from the stem and fruit of pineapple.4 Bromelain is thought to exert its anti-inflammatory effect by altering leukocyte migration and activation. Other mechanisms of action include proteolysis at point of inflammation, fibrinolysis via the plasminogen-plasmin system, depletion of kininogen, inhibition of inflammatory prostaglandins, and induction of prostaglandin E1 (an anti-inflammatory prostaglandin). Side effects of taking bromelain may include GI upset with diarrhea. Immunoglobulin E (IgE)-mediated allergic reactions are possible but this has not yet been widely documented.5

Was this article helpful?

0 0
Fitness Wellness For You

Fitness Wellness For You

Achieve the Fitness and Wellness for You that you have always wanted by learning the facts so you can take the right steps to maximize your health. Learn How to Achieve Real Fitness and Wellness for a Healthy Body, Mind and Spirit to Improve Your Quality of Life in Today's World. Receive Valuable Information to Discover What Really Matters and What Actually Works in Finding Genuine Wholeness for All Aspects of Your Being.

Get My Free Ebook

Post a comment