Pomegranate (Punica granatum)juice has shown several cardio-protective properties. In one study, consumption of 50 ml of pomegranate juice (1.5 mmol of total polyphenols) per day for two weeks in hypertensive individuals showed a decrease in angiotensin converting enzyme (ACE) activity by 36%. Additionally, there was a 5% reduction in systolic blood pressure.21 A similar study examined the effect of pomegranate juice consumption for one to three years in atherosclerotic patients with carotid artery stenosis. The results showed that, after one year, systolic blood pressure was reduced by 21%.22 Animal studies suggest that pomegranate juice inhibits the CYP3A4 enzyme comparable to the inhibition with grapefruit juice, which may alter the metabolism of pharmaceuticals metabolized with this pathway.23
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