Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to manage pelvic pain. Prostaglandins are responsible for much of the pain associated with endometriosis; because NSAIDs inhibit prostaglandin synthesis, they often reduce pain. Hormones typically used in treatment are danazol, a weak androgen that decreases follicle-stimulating hormone (FSH) and luteinizing hormone (LH) secreted from the pituitary gland, thereby inhibiting ovulation and menstruation; oral contraceptives; progestins; and gona-dotropin-releasing hormone agonists (GnRH agonists) thatsuppress FSH and LH and inhibitovulation. Studies have demonstrated reduction of symptoms in 67% or more individuals on oral contraceptive treatment (see the box on page 149 entitled "Pharmacologic Interventions for Treating Endometriosis'').30
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