Vinpocetine is another cognitive enhancer. It is derived from vincamine, a constituent of common periwinkle (Vinca minor). One study investigated 12-week oral vinpocetine therapy and blood flow parameters in patients with ischemic stroke and mild cognitive impairment both in resting conditions or following chemical stimulus, as well as the severity of mental deterioration. The results showed that vinpocetine treatment increased the blood flow velocity in resting conditions compared to baseline in the vascular group. The percent increase of mean velocity after the breath holding transcranial Doppler test showed a significant increase compared to the baseline in both ischemic stroke and mild cognitive impairment groups after 12 weeks of vinpocetine supplementation. Also, there was both objective and subjective significant improvement of cognitive functions with vinpocetine supplementation.31 Meta-analysis of three studies involving a total of 583 people with dementia treated with vinpocetine or a placebo showed benefit with treatment of vinpocetine 30 mg per day and 60 mg per day compared with a placebo.32

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