Progesterone is commonly prescribed to treat menopausal symptoms, abnormal uterine bleeding, premenstrual syndrome, endometrial hyperplasia, and infertility. Progesterone causes uterine smooth-muscle relaxation.57 Low levels of progesterone can cause a relative estrogen excess; excessive estrogen is implicated in endometriosis. Thus, a clinical trial of progesterone therapy in conjunction with immunologic and inflammatory modulation of the internal biochemical milieu appears to be a rational approach to treating endometriosis.
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