Silymarin, the main active constituent in milk thistle (Silybum marianum), has been shown to reduce TNF cytotoxic and pro-inflammatory functions.48 Constituents of milk thistle inhibit lipid peroxidation and are antioxidants and free-radical scavengers.49 Silymarin also prevents toxin penetration into liver cells and may be able to decrease toxic metabolite formation in the liver. In addition, estrogen clearance may be increased as a result of silymarin inhibition of beta-glucuronidase.50
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