Metformin hydrochloride is commonly prescribed to treat insulin resistance and glucose intolerance. This drug reduces fasting glucose levels and improves oral glucose tolerance in patients with type 2 diabetes, possibly by reducing glucose output from the liver. Studies performed on women with PCOS showed that metformin not only improved glucose tolerance but also reduced total testosterone and free testosterone, and increased the levels of SHBG.39 However, conflicting results in similar studies demonstrated that weight and obesity also play roles in the effectiveness of metformin, showing decreased effectiveness with increasing weight.40 A study on women with PCOS and oligo-ovulation showed that treatment with metformin caused 23% of the patients to ovulate.41 When metformin was combined with clomiphene citrate, the ovulation rate jumped to nearly 90% compared to 12% of women who took a placebo.42 Continuing metformin while pregnant has also been shown to decrease the rate of spontaneous abortions in women with PCOS.43 Metformin treatment may also provide cardiovascular benefits as studies have indicated that the drug decreases ET-1, PAI-1, and lipoprotein(a).16,44
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.