Iodine deficiency has been linked to an increased risk of gastric carcinoma. One study demonstrated an increased prevalence of gastric cancer and an increased risk of atrophic gastritis in areas with a greater than average prevalence of iodine-deficiency-related goiter. The researchers also reported that competitive inhibitors of intracellular iodine transport, such as nitrates, thiocyanate, and salt increased the risk of gastric cancer.38 Another study found a significant correlation between decreased mean urinary iodine levels and prevalence of stomach cancer, as well as a greater frequency of severe iodine deficiency in stomach cancer than in controls.39 There is also evidence for lower levels of iodine in cancerous gastric tissue than in surrounding normal tissue.40
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