Wellness is the state of existence that arises when health-sustaining homeostatic balance is gained and maintained. Individual and cumulative toxic exposures threaten this optimal homeostatic state. However, identifying and compensating for toxic exposure can minimize the detrimental effects of the exposure. General signs, symptoms, and risks that may indicate the presence of a high risk for toxic load include diabetes; congestive heart failure; obesity; history of alcohol abuse; psoriasis and other skin disorders; heavy exposure to industrial or household chemicals; frequent or recurrent use of medications; use of hormonal therapy, including hormone replacements and oral contraceptives; and disease states that alter liver, kidney, or GI functioning. Also, due to the sensitivity of the immune system, immunologic disorders may also be seen with toxic exposures such as autoimmune diseases, immune suppression, and chronic inflammation. The review below of the mechanisms of some of the most important protective and detoxifying pathways offers insights into how best to cope with and accommodate toxic burden risk factors, and how to intervene naturally.5,6
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