Congestive Heart Failure

Patients with congestive heart failure (CHF) experience reduced peripheral blood flow at rest and exercise. NO derived from arginine can assist regulation of blood flow in these patients. In a double-blind trial, investigators demonstrated a significant improvement in blood flow, arterial compliance, and functional status in patients who received doses ranging from 5.6 to 12.6 g of arginine, three times a day, for six weeks, over patients on a placebo.48 Another study demonstrated positive effects on kidney function (important in CHF) as evidenced by increased glomerular filtration rate, creatinine clearance, and elimination of sodium and water following saline loading.49

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