Patients with congestive heart failure (CHF) experience reduced peripheral blood flow at rest and exercise. NO derived from arginine can assist regulation of blood flow in these patients. In a double-blind trial, investigators demonstrated a significant improvement in blood flow, arterial compliance, and functional status in patients who received doses ranging from 5.6 to 12.6 g of arginine, three times a day, for six weeks, over patients on a placebo.48 Another study demonstrated positive effects on kidney function (important in CHF) as evidenced by increased glomerular filtration rate, creatinine clearance, and elimination of sodium and water following saline loading.49
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