Cobalamin (vitamin B12) is another B vitamin important for psychiatric health. A deficiency of vitamin B12 can lead to psychiatric symptoms; and this has been documented in the medical literature for several decades.30 In one particular study, the occurrence of manic psychosis in patients was evaluated. There was no apparent vitamin B12 deficiency, although there were changes in the patients' electroencephalograms along with mental changes.31 Citing the causal link between vitamin B12 deficiency and brain dysfunction, the authors of this study suggest that the manifestation of psychiatric symptoms may occur prior to other standard signs such as macrocytic anemia and spinal-cord disease, and that all patients with psychiatric disease should be evaluated for vitamin B12 deficiency.
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