Club Moss

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One of the chemicals found in a rare club moss (Huperzia serrata), huperzine A, has been studied in China for its effects on memory, cognition, and behavior in patients with Alzheimer's disease. Huperzine A inhibits acetylcholinesterase, protects cells against beta-amyloid protein, hydrogen peroxide, glutamate, ischemia, and staurosporine-induced cytotoxicity and apoptosis. These protective effects are due to the ability of huperzine A to attenuate oxidative stress, regulate the expression of apoptotic proteins, protect mitochondria, up-regulate nerve growth factor and its receptors, and interfere with amyloid precursor protein metabolism.27 Three double-blind trials enrolling a total of more than 450 people indicated that huperzine A can significantly improve symptoms of Alzheimer's disease and other forms of dementia.28-30

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