Constituents of black cohosh (Cimicifuga racemosa) are anti-inflammatory and have estrogenlike activity.53,54 Animal studies suggest that black cohosh suppresses pituitary secretion of LH. Studies indicate that the herb may be a selective estrogen receptor-modulator that has estrogenic effects on some tissues and antiestrogenic effects on other tissues.55 New data suggest that black cohosh does not bind estrogen receptors, stimulate the growth of estrogen-dependent tumors, or up-regulate estrogen-dependent genes.56
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