Aspirin is used to produce antipyretic, analgesic, and anti-inflammatory activity. Recent promotion of aspirin (e.g., Bayer Aspirin) as a prophylactic treatment to decrease platelet aggregation to prevent transient ischemic attacks, strokes, and thromboembolisms has increased the use of this over-the-counter medication.31
Treatment with aspirin, or acetyl salicylic acid, affects several nutrients. Many studies have shown that aspirin therapy decreases vitamin C absorption.32 Some studies also indicate that increasing aspirin dosage directly correlates to increasing ascorbic acid excretion in the urine.33 Research also suggests that aspirin therapy causes an increase in gastric blood loss leading to a decrease in total body iron.34 Evidence also shows that aspirin significantly decreases both total and bound serum folate, and increases folic-acid excretion slightly.35
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