Antiandrogens, such as spironolactone, are used to treat symptoms such as acne and hirsutism. This drug can cause menstrual abnormalities; thus, it is commonly used in conjunction with oral contraceptives. Other antimineralcorticoids, such as flutamine and cyproterone acetate (not available in the United States), have been effective for treating symptoms associated with androgen excess.45 Newer oral contraceptives, such as Yasmin, which contains drospirenone (a synthetic progestin/spirolactone analogue), is often prescribed for anti-androgenic activity.

GnRH Agonists

GnRH agonists, such as leuprolide, are used to suppress the pituitary-ovarian axis. This causes a decrease in ovarian secretion of estrogen and androgens. This drug is usually used for short periods of time because of the bone loss associated with hypoestrogenism.


Eflornithine is a topical treatment for hirsutism. It inhibits the enzyme ornithine decarboxylase in the skin. This causes a decrease in the rate of hair growth.


Clomiphine citrate is an antiestrogen used to increase LH and FSH to induce ovulation for enhancing fertility. Studies have shown that this agent can induce ovulation in approximately 80% of oligo-ovulatory women.46

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