Natural Multiple Sclerosis Treatment System
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). The disease is characterized by loss of myelin, the fatty tissue that surrounds and protects nerve fibers allowing them to conduct electrical impulses. In MS, scar tissue, or sclerosis, forms at the sites of demyelination, with destruction of neuronal axons and progressive neurologic disability. The National Multiple Sclerosis Society estimates that 400,000 individuals in the United States have MS.1
Multiple sclerosis or experimental autoimmune encephalomyelitis (EAE), circulating lymphocytes and monocytes macrophages readily cross the blood-brain barrier and gain access to the CNS leading to edema, inflammation, and demyelination. Also often used to modify the disease process in MS is glatiramer acetate, a mixture of synthetic polypeptides composed of four amino acids, and based on the structure of MBP, which is believed to inhibit the T-cell response to multiple antigens in myelin. Glatiramer acetate induces T-regulatory cells known as GA-specific regulatory CD4 and CD8 lymphocytes, as well as causing a shift from Th1 to Th2 activity, increasing the secretion of anti-inflammatory cytokines and suppressing the autoimmunity led by Th1 cells.18 Free radicals are believed to play a role in the pathogenesis of multiple sclerosis.
Use of enzymes in controlling fibrin can be applied in several other disease models. One interesting aspect of fibrin control is the use of fibrinolytic enzymes in multiple sclerosis (MS). Researchers at the University of California, San Diego, School of Medicine found that, when fibrin was removed from the body (in animal models of MS), tissue damage resulting from MS was decreased and the life spans of animals were lengthened. These animals had decreased inflammatory measures and expression of major histocompatibility complex class I antigens, and reduced demyelination.9 Fibrin is, however, better known for its role in blood clotting.
The herb has received much attention recently because of the detection of an endogen cannabionoid system in the human brain and the immune system. The endogen cannabionoid system plays a significant role in memory, appetite, lactation, and emesis. Muscle-relaxant, appetite-stimulating, and analgesic effects of (-) trans-delta 9- tetrahydrocannabinol or THC (Fig. 5.205, Chapter 5), are of great interest. A comparative study of cannabis has shown better antispastic activity than THC, as measured in an immunogenic model of multiple sclerosis. The synergistic effect demonstrated with cannabis extract is probably due to presence of cannabidiol or CBD (Fig. 6.9) in the extract, which elevates the level of THC in the brain and at the same time, attenuates the undesired anxiolytic effect of THC. At the same time CBD amplifies the antispastic effect of THC. Amplification of the antispastic effect is not understood but it is assumed that CBD increases the permeation of THC into the muscles.
Animal studies have demonstrated that cimetidine significantly decreases intestinal calcium transport.20 Cimetidine also alters vitamin D metabolism by altering the enzyme vitamin D 25-hydroxylase activity, suppressing the seasonal increase in the level of 25-hydroxyvitamin D. The levels of 25-hydroxyvitamin D rose significantly after withdrawal of the drug.21 A small study performed with the PPI omeprazole demonstrated that serum levels of beta-carotene were decreased with increased gastric pH.22 These findings raise the question of the long-term potential consequence for increased risk of osteoporosis, other vitamin D-linked disease states, such as various cancers and multiple sclerosis, and altered RNA and DNA production as a consequence of lowered B12 and folate.
P Securinine was found to have an action similar to strychnine (Quevauviller et al., 1967). In pharmacological and clinical trials, Tourova (1957) noted that the alkaloid stimulates the CNS, including the spinal cord. In clinical trials with the nitrate (200 cases), Tourova (1957) observed that a rapid re-establishment of motility was produced, and hence it seems indicated in paresis, paralysis in poliomyelitis and diphtheria, and in apoplectic paresis and paralysis. The use of securinine is also indicated for impotence, decrease of cardiac activity, functional amaurosis, asthenia consecutive to extenuating diseases and ocular nerve atrophy. The drug was administered either by mouth (10-20 drops daily of a 1 250 solution of securinine nitrate) or subcutaneously (1 ml of a 1 500 solution daily). With these doses, no secondary effects have been noticed but overdosage produces a painful tension in the nape of the neck, face muscles and other muscle groups. In China securinine is used in...
Only be used as a short-term treatment. Stimulation of the immune system will be detrimental in autoimmune disorders (such as multiple sclerosis) or in disorders where a heightened immune response may be counterproductive (such as AIDS, asthma, leukemia, and tuberculosis) hence Echinacea is con-traindicated in their treatment (Blumenthal et al., 1998).
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