How I Survived Melanoma Skin Cancer

How To Prevent Skin Cancer

How To Prevent Skin Cancer

Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.

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How I Survived Malignant Melanom

By The Time You've Finished Reading How I Survived Melanoma Skin Cancer Seven Survivors Tell Their Stories. You'll Feel Like A New Person, with A New, More Positive Outlook! You will learn: 1. How do I know if I have melanoma? What are the signs and symptoms? I wanted to know why the doctor was so concerned when she looked at that little mole on my forearm. What was it that looked so sinister? How worried should I be? Was the doctor over-reacting? 2. What tests will the doctor carry out to see if I have melanoma? Will they be able to tell me on the spot if there is a problem? Or will I have to wait for days, fretting about whats going on? 3. How curable is melanoma? If they do tell me its melanoma, what exactly does that mean? Is it a death sentence? Will they tell me You have 12 months to live. Get your life in order and prepare for the worst.? 4. What are the stages of the disease? The reading Id done said that there were different stages of melanoma. What are the symptoms of each stage? What are the survival rates of each stage? If I had a later stage melanoma, wouldnt I know about it? Wouldnt I actually feel like I was sick? 5. How quickly does the disease progress or spread? Should I have gone to the doctor sooner? Id noticed the mole changing over about 3 months. Was this delay critical? 6. How is melanoma normally treated? Would I have to go through chemotherapy and radiation treatment? If so, for how long? What are the odds of curing the disease using these treatments? How extensive is any surgery likely to be? How big will the scars be? 7. What are the common side effects of the treatments? Would I lose my hair? Would I become sterile? What else could I expect? 8. What alternative treatments are available? Id heard of people going on special macro-biotic diets. Id seen lots of herbal remedies on the internet. Which of these are proven and documented, and which ones are snake oil? Is it possible to combine alternative treatments with surgical other western treatments? How do I find a doctor that is open to using both alternative and western treatments? 9. What are the latest treatments being developed, and who is carrying out clinical trials of these new treatments?

How I Survived Malignant Melanom Summary


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Author: Daryl Grant
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The author presents a well detailed summery of the major headings. As a professional in this field, I must say that the points shared in this book are precise.

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Ultraviolet Light And Skin Cancer Mutation And Immunity

Excessive exposure to UV radiation causes sunburn, premature aging of the skin, and mutations leading to skin cancer (Urbach, 1978). A gradual thinning of the ozone layer, which helps to screen our planet from solar radiation, and an increase in recreational sun exposure in the general population are thought to be significant factors underlying the steady rise in the incidence of all types of skin cancers over the past twenty years (Fears and Scotto, 1983 Green etal, 1985). The non-melanoma types of skin cancer (NMSC), squamous cell carcinoma of the skin and basal cell carcinoma (Weber, 1995), are the most common forms of human neoplasm, representing one-third of all new malignancies diagnosed in the United States (Strom and Yamamura, 1997). The number of new cases of NMSC diagnosed in the United States per year is approaching one million and continues to rise (Boring etal, 1992). Fortunately, NMSC has low mortality although it has considerable morbidity, causing disfigurement, loss...

Dna Damage And Repair

Excision repair involves recognition of DNA lesions, nicking of the damaged DNA close to the damage, removal of the damaged fragment, and resynthesis with the intact strand as a blueprint to fill in the gap. Certain yeast rad mutants and the seven complementation groups of the heritable human disease xeroderma pigmentosum (XPA-XPG) are deficient in components of the nucleotide excision repair machinery. This deficiency leads to an extreme UV sensitivity and skin cancer predisposition in XP patients (e.g. Friedberg, 2001). A number of Arabidopsis mutants with UV-B hypersensitivity are impaired in homologues of these human and yeast proteins UVH1 (human XPF yeast RAD1 homologue, Fidantsef et al., 2000 Liu et al., 2000), UVH3 UVR1 (XPG RAD2 homologue, Liu et al., 2001), UVH6 (XPD RAD3 homologue, Liu et al., 2003), and UVR7 (ERCC1 RAD10 homologue, Hefner et al., 2003). Thus, the nucleotide excision repair pathway appears to be functionally conserved in plants and to play a crucial role in...

Antihistamine and antiinflammatory activities of barbaloin

Aloe Vera Anatomy Images

It is well known that Kidachi aloe extract shows skin-whitening activity and the active component is barbaloin. Recently, aloesin esters as well as barbaloin, were found as the active inhibitory components against mushroom tyrosinase, which converts tyrosine into melanin. The active components were determined to feruloyl- and -coumaroyl aloesin (Yagi etal, 1987a). The skin-whitening activity of semi-synthetic aloesin derivatives was demonstrated by monitoring on rat melanoma cells (KB cells) and in clinical tests (Jones, 1999).

General Requirements For Promoting Healthy Skin

Lifestyle factors are critical for maintaining healthy skin. Smoking can cause dryness and premature aging of the skin. Sun exposure is associated with an increased risk of skin cancer, premature aging, and hyperpigmentation of the skin, requiring a limit to sun exposure and the use of sunscreen during prolonged exposure. Clinically, exercise has been shown to help promote a radiant, glowing complexion.

Immunomodulatory action

Aloe gel may also directly stimulate the immune system (Womble and Helderman, 1988) through its active ingredient acemannan. This polysaccharide increases lymphocyte response to alloantigen it activates macrophages to produce nitric oxide (Karaca etal, 1995) and cytokines (interleukins 1 and 6, interferon, tumor necrosis factor) it enhances phagocytosis (Shida etal., 1985) and, it increases the number of circulating monocytes and macrophages. Aloe gel also causes a local activation of complement at the level of C3. Recently Qiu etal. (2000) have developed a process to activate and stabilise aloe polysaccharide. Modified aloe polysaccharide (MAP) prevents ultraviolet (UV) irradiation-induced immune suppression as determined by contact hypersensitivity response in mice. MAP also inhibits UV irradiation-induced TNF (tumour necrosis factor) release from human epidermoid carcinoma cells. All these results indicate that MAP can be used to reduce the risk of sunlight-related human skin...

Is there such a thing as immunity to cancer

Recently, Markiewicz and Gajewski (1999) reviewed the history of immune surveillance beginning with the discoveries of the 1960s, through the disappointments of the 1980s and the new hopes of the 1990s. First, immunologists realized that cancers contain tumor specific antigens which are developmental and oncogenic markers. On occasion, tumors contained viral antigens. However, attempts in the 1980s to develop cancer vaccines or to upregulate the immune response with BCG or Interleukin-2 were singularly unsuccessful. These failures led many to doubt the existence of immune surveillance (Stutman, 1974, 1979 Klein and Boon, 1993) but, as experience with immunotherapy of cancer increased, it became clear that human neoplastic disease is much more complex than any mouse model. The evidence for protective immune involvement in cancer is summarized by the reviews cited in Table 12.1 below. To paraphrase Markiewicz and Gajewski, we now know that in humans (i) immunosuppression increases the...

The Immune System and Cancer Prevention

By boosting the immune system, it has been claimed that fructooligosaccharide supplements reduce the risk of colorectal cancer developing (Kowhi et al., 1978, 1982 Pool-Zobel et al., 2002). In mice and rats, for example, fructooligosaccharides reduced colon carcinogens and the occurrence of colon tumors (Pierre et al., 1997), while dietary inulin and fructooligosaccharides suppressed chemically induced tumors (Taper and Roberfroid, 2002) and reduced genotoxic damage to the colonic epithelium in rats (Rowland, 1998). The release of the short-chain fatty acid butyrate, from fermenting inulin and fructooligosaccharides, may play a role in suppressing colon cancer. Butyrate has been shown to have a direct antiproliferation effect on tumor cells in vitro (Kruh, 1982), while the release of butyrate has been correlated with a protective effect against colon cancer in experimental studies with rats (Bornet, 2001 McIntyre et al., 1993). Moreover, inulin injections can prolong the survival of...

Conclusion And Future Directions

First, our studies have shown that there are multiple mechanisms operating in UVB-induced suppression of the skin immune system. The wider spectrum of purified, structurally-defined therapeutic ligands we are developing is likely to reveal further complexity of a detailed mechanism. Second, we expect that, together with our collaborators at the University of Georgia, we shall further define the complexity of mechanism of this UVB suppression. This will lead us to the discovery of further novel compounds in the same way as our prior work on the mechanism of aloe led to the discovery of the immune-protective activity of the Tamarind saccharides. Third, our mechanistic studies on the respective roles of CHS, DTH and suppressor cells help us to determine which test best correlates with UVB facilitation of tumor growth. This knowledge will set the stage for selection of the best surrogate for use in future clinical investigations of the efficacy of therapeutic saccharides in humans exposed...

Preface for the ESP series in Photochemical and Photobiological Sciences

It's not the substance, it's the dose which makes something poisonous When Paracelsius, a German physician of the 14th century made this statement he probably did not think about light as one of the most obvious environmental factors. But his statement applies as well to light. While we need light for example for vitamin D production too much light might cause skin cancer. The dose makes the difference. These diverse findings of light effects have attracted the attention of scientists for centuries. The photosciences represent a dynamic multidisciplinary field which includes such diverse subjects as behavioral responses of single cells, cures for certain types of cancer and the protective potential of tanning lotions. It includes photobiology and photochemistry, photomedicine as well as the technology for light production, filtering and measurement. Light is a common theme in all these areas. In recent decades a more molecular centered approach changed both the depth and the quality...

Air Quality

Improving air quality has been an imperative of environmental policies throughout the 20th century. Installation of filtering devices in power plants, the switch to less polluting fuels and other technical measures have achieved significant improvements in this respect. Yet air quality remains a major concern. While the concentration of air pollutants such as sulfur dioxide has been successfully reduced in urban areas, other - mainly car induced - pollutants such as nitrogen oxides, ozone and volatile organic compounds are of increasing concern. Climate change is likely to add further to these air quality problems because rising air temperatures and higher levels of radiation can lead, for instance, to higher concentrations of ozone in the air. Particular attention also needs to be paid to ultraviolet radiation, which can cause skin cancer, in the southern parts of Europe.


One of the most frequent therapeutic uses of medicinal mushrooms is for immune enhancement. While not the leading mushroom for this purpose, cordyceps nonetheless has some value. Several studies demonstrate the ability of the fungus to affect immune-cell function and populations. In one experiment, cordyceps use led to a significant increase in the number of T-helper leukocytes and increased the ratio of T-helper to T-suppressor cells.11 Other studies showed that cordyceps could enhance natural-killer (NK) cells as well as certain CD marker designations and their binding abilities on lymphocytes in people with leukemia.12 Cordyceps was also shown to inhibit the formation of melanoma in laboratory animals treated with a fungal extract researchers attributed this effect to improved NK cell function.13


Most types of DNA damage cannot be directly reversed, but are instead excised, and the resulting gap filled using the undamaged strand as a template, resulting in error-free repair. A variety of lesion-specific glycosylases have evolved that recognize commonly occurring oxidized or alkylated bases and so initiate base excision repair 29 . An additional mechanism, termed nucleotide excision repair (NER), recognizes, with varying efficiencies, a wide variety of damage products. In organisms such as Humans that lack photolyase activity, NER is a critical pathway for repair of UV-induced damage. As mentioned above, in Xeroderma pigmentosum patients defective in NER, exposure to sunlight results in hospitalization, and skin cancers appear at an early age. undergoing this response to UV irradiation 42 . In haploid cells (such as yeast) permanent arrest is the genetic equivalent of death. For this reason irradiated yeast and bacteria will first respond to damage by inducing repair, and if,...


Epidemiological data have shown that chronic exposure of humans to inorganic arsenical compounds is associated with liver injury, peripheral neuropathy, and increased incidence of cancer of lung, skin, bladder, and liver 9,237 . Arsenic can also cross the placenta and can cause fetotoxicity, decreased birth weight, and congenital malformation 196 . Several mechanisms have been implicated in arsenic-induced genotoxicity, which includes oxidative stress 238,239 . DNA repair inhibition 240,241 and direct mutagenesis 242 have been reported. In humans, an increased percentage of apoptosis was found in the buccal epithelial cells from individuals chronically exposed to arsenic in China 243 . Inorganic arsenic is a known human carcinogen causing lung cancer by inhalation and skin cancer via ingestion 244 .


Diagrams Medicinal Plants

(Fig. 5.114) from Polanisia dodecandra inhibits a broad panel of cancer cells central nervous system cancer (SF-268, SF-539, SNB-75, U-251), nonsmall- cell lung cancer (HOP-62, NCI-H266, NCI-H460, NCI-H522), small-cell lung cancer (DMS-114), ovarian cancer (OVCAR-3, SKOV- 3), colon cancer (HCT-116), renal cancer (UO-31), a melanoma cell line (SK-MEL-5), and leukemia cell lines (HL-60, SR), cultured in vitro.

Prostrate Spurge

The bad-boy member of the family is leafy spurge (Euphorbia esula), an invasive weed of cattle rangeland that is so unpalatable that cattle won't even graze near it. Leafy spurge, then, shrinks the effective acreage available for feeding. The most useful member of the family is petty spurge (Euphorbia peplus), which is interesting for its oddly personified name, but useful because its milky sap can be used as an out-of-the-ground treatment for skin cancer lesions. The sap is applied to the lesion like liquid nitrogen, and like liquid nitrogen it causes skin blistering and cell death where it is applied. The cancer generally flakes off a week or so later. The milky sap is common to most members of the Euphorbia family. Break a leaf off your poinsettia and watch the sap run. Cactus-like members of the family can be distinguished from real cacti, whose family is conveniently called the Cactaceae. Euphorbia cacti are like cows they have two horns and give milk. (Translation The spines...


Research at the University of Texas has demonstrated that curcumin blocks the activity of a hormone having a link with the development of colorectal cancer. Other studies have demonstrated that curcumin inhibits melanoma cell growth and destroys cancer cells. In addition, animal research conducted at the University of Texas reported that curcumin prevented the spread of breast cancer cells to lungs.

Modern Uses

Extracts of A. absinthium have been shown to possess a range of biological activities, including insecticidal action of an alcoholic extract against the stored crop pest Sitophilus granarius (Ignatowicz and Wesolowska, 1994) and nematocidal action against Meloidogyne incognata (Walker, 1995) and Helicotylenchus dihystera (Korayem et al., 1993). The antimalarial activity, against Plasmodium falciparum, of two diastereomeric homoditerpene peroxides from the aerial parts of A. absinthium was demonstrated (Rucker et al., 1991 1992) while Zafar et al. (1990) screened aqueous and alcoholic extracts against a strain of Plasmodium berghei in mice, demonstrating their pronounced schizontocidal properties. Other interesting properties attributable to wormwood extracts include the hepatoprotective effects of an aqueous methanolic preparation wherein the mode of action was suggested to involve partly the inhibition of microsomal drug metabolising serum transaminase enzymes (Gilani and Jambaz,...