The molecular basis for the lipid-lowering action of guggulsterones has been suggested to be an antagonism of the farnesoid X receptor, a member of the nuclear receptor super family of ligand-activated transcription factors. Guggulsterones activate the estrogen receptor, progesterone receptor, and pregnane X receptor with EC50 values in low micromolar range. Guggulsterone-mediated activation of pregnane X receptor induces the expression of CYP3A genes both in rodent and human hepatocytes. Pregnane X receptor activation is known to cause herb-drug interactions and it has been suggested that guggulipid therapy should be used cautiously in patients taking prescription medications that are metabolized by the CYP3A family members.
Was this article helpful?
Discover How To Use Herbal Medicine Effectively To Heal Away Disease amp illnesses That Most Of The Herbalist Do Not Want You To Know About. If You Have Never Know What Is All About Herbal Medicines amp The Correct Way Of Using Herbs To Build A Healthier Life, Then This Guide Is About To Reveal All Just That.