Furanocoumarins

These are photosensitizing agents used in the treatment of pigment disorders. Ayurveda, the ancient science of India, has described the use of Psoralia corylifolia for the treatment of leucoderma. Psoralens isolated from the medicinal herb, are reputed drugs in the field of dermatology. Furanocoumarins are present in Ficus carica, Apium graveolens, Ruta graveolens and Angelica gluca. Marmelosin present in Aegle marmelos is the precursor compound for psoralen biosynthesis. Xanthotaxol from Angelica archangelica exhibited potent peripheral anti-OH-tryptamine acitivty in rat isolated fundal strip, also antihistaminic and antinicotinic activites on guinea-pig ileum.

Furfural Plant

h3c^

Imperatorin

IsopimpineHin h3c^

Imperatorin

IsopimpineHin

Sphondin

Sphondin

"Q

"Q

Psoralen

Trioxsalen

Xanthotaxol

Trioxsalen

Xanthotaxol

H3C\

Xanthotoxin (ammonidin) Fig. 5.138 Structure of common Furanocoumarins.

Furanocoumarins

OH OH

Heraclenol

Fig. 5.139 Structure of more Furanocoumarins.

Table 5.6 Furanocoumarins of Genus Heracleum.

Species

Coumarin

H. candicans

Heraclenin, heraclenol, bergapten, candicanin, candicopi-maric acid

H. canescens

Xanthotoxin, imperatorin, heraclenin, bergapten, isopimpinel-lin, osthol and heraclenol

H.cachemiricum

Xanthotoxin, imperatorin, heraclenin, bergepten, and heracle-nol

H.obtusifolium

Isoimperatorin

H. nepalense

Bergapten, isobergapten, sphondin and isopimpinellin

H.pinnatum

Xanthotoxin, imperatorin, heraclenin, bergapten, isopimpinel-lin, heraclenol and xanthotaxol

H. rigens

Heraclenin, isopimpineHin,osthol, imperatorin, bergapten and isobergapten

H.sublineare

Bergapten, isobergapten, sphondin and isopimpinellin

H. thomsoni

Psoralen, 5-hydroxyangelicin, heratomol, angelicin, lanatin, osthol, isobergapten, isopimpinellin, bergapten, sphondin and apterin

H.wallichii

Bergapten, isobergapten, sphondin, isopimpinellin, columbi-anetin, mrmesin nd vaginidiol

Source: RRL, Jammu.

Source: RRL, Jammu.

Table 5.7 Furanocoumarins studied from medicinal plants.

S.No

Name of the furanocoumarins

Source

1.

Angelicine

Angelica archangelica

2.

Bergaptan

Psoralia corylifolia

S.

Heraclenin & Heraclenol

Heracleum candicans, Opopanax chiro-nium, Ruta montana,

4.

Imperatorin

Psoralia corylifolia

5.

Isopimpinellin

Psoralia corylifolia

6.

Oxypeucedanin

Ficus pumila

7.

Psoralen

Psoralia corylifolia

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