Clinical studies

Chronic colitis

A study reported the efficacy of polyherbal formulation containing T.officinale in chronic pain associated with colitis. As multiple herbs were used, and this study was not well-designed or reported, the effects of dandelion are not clear.

Hepatitis B

One human study, reported improved liver function in people with hepatitis B after taking a combination herbal preparation containing T.officinale, Artemisia capillaries Thunb (Asteraceae), Taraxacum mongolicum Hand-Mazz. (Asteraceae), Plantago ovata Forssk. (Plantaginaceae), Cephalanoplos segetum (Bunge) Kitam (Asteraceae), Hedyotis diffusa Willd. (Rubiaceae), Chrysanthemum indicum Linn. (Asteraceae), Smilax glabra Roxb. (Smilaceae), Astragalus membranaceus (Fisch.ex Link.) Bunge (Fabaceae), Salvia miltiorrhizae Bunge. (Lamiaceae), Polygonum orientalis L. (Polygalaceae), Paeonia alba L. (Ranunculaceae), and Polygonatum sibiricum F. Daelaroche. (Convallariaceae). Since polyherbal preparation was used in the study, the possible benefits of T.officinale need to be explored.

Studies have indicated that chicoric acid inhibits the penetration of viruses in cells. Chicoric acid also acts as an antioxidant by preventing the oxidation of collagen and cells. Chlorogenic acid is cholagogue; its regular ingestion helps the flow of bile and thus reduces the adverse effects of bile stagnation. While chlorogenic acids are not the only compounds that serve well as cholagogues, the evidence for their effectiveness is by far the strongest. Both chicoric and chlorogenic have an action on the heaptobiliary apparatus and therefore the role in extracts of T. officinale needs further exploration.

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