Longevity Health and Wellness Protocol
Calorie restriction is one of the most supported interventions in aging and longevity research. Studies with numerous animal types have demonstrated that calorie restriction increases longevity and decreases age-related diseases. Calorie restriction is widely studied in attempts to define which biochemical pathways are affected by fasting and the induced stress response. Research with humans indicates that calorie restriction modulates energy metabolism, reduces free-radical production, and alters endocrine function.38 A study with monkeys demonstrated that a 30 reduction in calories lowered core body temperature and decreased energy expenditure.39 Calorie restriction also increases the levels of nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases (known as sirtuins), which are involved in energy metabolism and gene silencing, and are associated with increased longevity.40 Specifically, Potential Anti-aging Supplements
Photosynthesis of higher plants responds irreversibly to water stress. Lichens in contrast respond reversibly to desiccation. Leaves respond to environmental conditions by modifying the ageing process which is species-specific. There is a tendency towards optimisation of C02 assimilation and transpiration, although the optimal response (water
Due to the revised interest in herbal medicine, people are favoring nutraceuticals and botanical supplements. As the same time several companies have introduced designed or pharma foods in the market. These are a rich source of phytochemicals having antioxidant, anti-aging and chemo protective effects. Recent studies have reported that phytomedicines have a modulatory effect on drug-metabolizing enzymes, (particularly cytochrome 450) leading to potential drug interactions. Phytochemicals have the tendency to elevate as well as suppress the cytochrome 450 system.
During centuries, a vital strength was assumed to have conferred on inanimate matter the property of becoming alive and of continuing to promote the spontaneous generation of living organisms from non-living material however, not everyone agreed with this. The controversy continued to increase until the nineteenth century when all the experiments purporting to prove spontaneous generation were shown to be erroneous see, for instance, Spallanzani (1787) and Pennetier (1907) . Chemists succeeded in the abiotic synthesis of organic compounds (thus demonstrating that the substances produced by living processes and by artificial synthesis were not different in essence) and the theories of vitalism and spontaneous generation were abandoned.
The interest in citrus flavonoids was determined by research carried out by Armentano etal. (1936) and Rusznyak and Szent-Gyorgyi (1936), who reported that 'Citrin', a crude mixture of flavonoids prepared from lemon peel, was effective in reducing capillary permeability in man, in prolonging life and mitigating tissue hemorrhaging due to scurvy in guinea pigs. The group of substances responsible for these effects was considered to be a vitamin, and was given the name 'Vitamin P'. Successive research was unable to demonstrate that flavonoids are necessary factors in the diet, and the term 'Vitamin P' fell into disuse, and was replaced by the term 'bioflavonoids' (flavonoids having a biological activity).
The most crucial consideration when devising a comprehensive health intervention is understanding how to prevent or slow the degenerative process best. Without question, dietary factors constitute the single most important preventive focus. In one prospective study, 586 participants without clinical symptoms of dementia, age 55 or older, had their diets assessed at the beginning of the study and were screened for symptoms of dementia an average of two years later.2 After adjusting for other factors, such as age, gender, and education, subjects with the highest total fat intake had a significantly elevated relative risk (RR) of dementia (RR 2.4 1.1-5.2 ). Other dietary factors associated with an increased risk of dementia were a high intake of saturated fat (RR 1.9 0.9-4.0 ) and cholesterol (RR 1.7 0.9-3.2 ). An encouraging finding was that a high intake of fish was associated with a significantly lower risk of dementia in general (RR 0.4 0.2-0.91 ) and was particularly associated with...
Dimethylaminoethanol (DMAE) is a naturally occurring substance that has been studied as a possible anti-aging therapy that improves cognitive function. DMAE is the precursor to choline and may increase acetylcholine levels.41 DMAE inhibits production of the age-related pigment lipofuscin, which accumulates in all aging tissues. This is significant because cells with
Merriam, E.A., Campbell, B.S., Flood, L.P Welsh, C.J.R., McDaniel, H.R. and Busbee, D.L. (1996) Enhancement of immune function in rodents using a complex plant carbohydrate, which stimulates macrophage to secretion of immunoreactive cytokines. In Advances in Anti-Aging Medicine, 1, 181-203. New York Mary Ann Liebert, Inc.
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