The DNA repair response includes different pathways, such as photoreactivation or direct repair, mismatch repair (MMR), base excision repair (BER), nucleotide excision repair (NER), nonhomologous end joining (NHEJ), and homologous recombination (HR). Photoreactivation is a mechanism of UV-damage DNA repair that is performed by photolyases using the energy of visible light. In MMR, NER, and BER, damaged bases are excised from the genome and replaced by corrected nucleotides following the most common DNA repair rules. HR and NHEJ are responsible for repairing double strand breaks (DSB) (Kimura and Sakaguchi 2006; Balestrazzi et al. 2011).
Was this article helpful?