Effect of Other Additives on Antimicrobial Activity

Other commonly used excipients were examined for their effect on the anti-microbial activity of tea tree oil. Simple 0.5% aqueous solutions, solubilised with polyoxyl 35 castor oil, were

Tea tree oil concentration 0.1%

Fails some bacteria

Fails Candida and A. niger

Passes bacteria

Passes Candida

Fails A. niger

Result (combined BP/USP test)

again used. The materials examined included EDTA, oil of thyme, propylene glycol and butylene glycol. All materials were examined in a range of concentrations, and it was found that none of the materials examined had any observable effect on the anti-microbial activity of the oil.

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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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