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Herbalphytochemicaldrug interactions

Health Benefits Henbane

Due to the revised interest in herbal medicine, people are favoring nutraceuticals and botanical supplements. As the same time several companies have introduced designed or pharma foods in the market. These are a rich source of phytochemicals having antioxidant, anti-aging and chemo protective effects. Recent studies have reported that phytomedicines have a modulatory effect on drug-metabolizing enzymes, (particularly cytochrome 450) leading to potential drug interactions. Phytochemicals have the tendency to elevate as well as suppress the cytochrome 450 system. Some of the best-selling herbal supplements are ginkgo (Ginkgo biloba, used for increasing peripheral blood flow and in senile dementia), Asian Korean ginseng (Panax ginseng, used as an 'adaptogen' to help regulate the body's reaction to various stresses), garlic (Allium sativum), used for cardiovascular health including hypercholesterolemia), echinacea (Echinacea purpurea angustifolia), used to support the immune system,...

Some Natural Medicines May Alter Laboratory Test Results

Drug-drug interactions occur, and it follows quite logically that drug-natural medicine interactions also happen. These potentials for side effects and interactions, however, are not limited to botanical medicines, supplemental forms of vitamins, minerals, and other nutrients when they are taken at doses and durations that do not occur naturally. We have moved beyond the concept of food as the best medicine'' into an arena of actively, and sometimes aggressively, manipulating and changing the biochemical balance of these substances in a broad and global fashion that increases the likelihood of both altered physiologic and chemical functioning, producing both positive and, at times, negative effects. Because integrative medicine practitioners combine natural therapies with conventional ones, it is vital to have a sophisticated understanding of these medicines, particularly how they interact with conventional drugs. This is a topic that is now receiving more attention in the literature....

Guggulsterones Fig 5205

The molecular basis for the lipid-lowering action of guggulsterones has been suggested to be an antagonism of the farnesoid X receptor, a member of the nuclear receptor super family of ligand-activated transcription factors. Guggulsterones activate the estrogen receptor, progesterone receptor, and pregnane X receptor with EC50 values in low micromolar range. Guggulsterone-mediated activation of pregnane X receptor induces the expression of CYP3A genes both in rodent and human hepatocytes. Pregnane X receptor activation is known to cause herb-drug interactions and it has been suggested that guggulipid therapy should be used cautiously in patients taking prescription medications that are metabolized by the CYP3A family members.