2.5.1 escop* Monograph Matricariae flos — Matricaria Flower (; See also Chapters 11 and 12)
Matricariae flos Matricaria Flower
Matricaria flower consists of the dried flower heads of Matricaria recutita L. (Chamomilla recutita [L.] Rauschert). It contains not less than 4 ml/kg of blue essential oil.
* European Scientific Cooperative on Phytotherapy.
The material complies with the European Pharmacopoeia .
Fresh material may also be used provided that when dried it complies with the European Pharmacopoeia.
The main characteristic constituents of matricaria flower are the essential oil and flavone derivatives [21, 32, 60, 98, 116] such as apigenin-7-glucoside (approximately 0.5%) .
The essential oil contains approximately 50% of the sesquiterpenes (-)-a-bisabolol and its oxides A and B , bisabolonoxide, up to 25% of cis- and trans-en-yn-dicycloethers (or spiroethers) , and matricin, which is converted to chamazulene on distillation (up to 15%) .
Other constituents of matricaria flower include coumarins (herniarin and umbelliferone) [21, 32, 98, 116], phenolic acids [21, 32, 98], and polysaccharides (up to 10%) [21, 32, 52, 98].
188.8.131.52 Clinical Particulars
184.108.40.206.1 Therapeutic indications
Symptomatic treatment of gastrointestinal complaints such as minor spasms, epigastric distension, flatulence, and belching [24, 27, 32, 45, 60, 65, 83, 93, 112]
Minor inflammation and irritations of skin and mucosa, including the oral cavity and the gums (mouthwashes), the respiratory tract (inhalations), and the anal and genital areas (baths, ointments) [24, 27, 28, 35, 50, 54, 69, 74, 78, 83, 85, 86, 94, 96, 99, 105, 111, 112]
220.127.116.11.4 Posology and method of administration
18.104.22.168.6 Internal use
Adults: As a tea infusion: 3 g of the drug to 150 ml of hot water, three to four times daily Fluid extract (ethanol 45-60%): Single dose 1-4 ml [4, 32] Dry extract: 50-300 mg three times daily  Elderly: Dose as for adults
Children: Proportion of adult dose according to age or body weight
22.214.171.124.7 External use
For compresses, rinses, or gargles: 3-10% m/V infusion or l% V/V fluid extract or 5% V/V tincture [32, 64]
For baths: 5 g of the drug, or 0.8 g of alcoholic extract, per liter of water 
For solid and semisolid preparations: Hydroalcoholic extracts corresponding to 3-10% m/m of the drug [60, 116]
For vapor inhalation: 10-20 ml of alcoholic extract per liter of hot water 
126.96.36.199.8 Method of administration
For oral administration, local application, and inhalation Duration of administration No restriction
188.8.131.52.9 Contraindications Sensitivity to Matricaria or other Compositae
184.108.40.206.10 Special warnings and special precautions for use None required
220.127.116.11.11 Interaction with other medicaments and other forms of interaction None reported
18.104.22.168.12 Pregnancy and lactation No harmful effects reported
22.214.171.124.13 Effects on ability to drive and use machines None known
Rare cases of contact allergy have been reported in persons with known allergy to Artemisia species . Matricaria flower of the bisabolol oxide B-type can contain traces of the contact allergen anthecotulide [27, 62, 98]. Matricaria recutita L. possesses a much lower allergenic potential than other chamomile species, and therefore allergic reactions to Matricaria must be considered as extremely rare. Most of the described allergic reactions to Matricaria were due to contamination with Anthemis cotula or related Anthemis species, which contain high amounts of anthecotulide. However, in cases where Matricaria contact allergy has been acquired, cross-reactions to other sesquiterpene lactone-containing plants are common .
126.96.36.199.15 Overdose No toxic effects reported
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