Info

No Treatment

Vehicle to back

1.67% Aloe to back

5000 Joules/m2 to back skin

71%

55%

Values summarize data from Figure V in Strickland et al. (1994). Significant suppression was observed in both the UV exposed/untreated group and the UV exposed/vehicle treated group, p = 0.01 by ANOVA. There was no suppression in the UV exposed/aloe treated group.

Note

Values summarize data from Figure V in Strickland et al. (1994). Significant suppression was observed in both the UV exposed/untreated group and the UV exposed/vehicle treated group, p = 0.01 by ANOVA. There was no suppression in the UV exposed/aloe treated group.

locally, it is not absorbed in sufficient quantities to treat the immune suppression being induced on the opposite side of the animal.

If a sufficiently high dose of UVB irradiation, a solid sunburn dose, is given, there is a suppression of the ability to induce a CHS response throughout the animal (Noonan etal, 1981, 1984). For example, if enough UVB is given to the skin of the back, and painting hapten on non-UV-exposed abdominal skin of the mouse will not sensitize it, there is systemic suppression of CHS responses. We tested whether aloe extract would be protective against a sunburn-range dose of UV. The backs of mice were exposed to 10,000Joules/m2 UV radiation which is about five times the MED of the C3H mouse. The back skin was then treated with the highest dose of ARF Process A gel or the Aquaphor vehicle and the experiment completed as above.

Even at this high dose, one that if repeated is capable of inducing skin cancer in this strain of mice, the gel was capable of restoring the CHS response (Table 12.7).

Effects of A. barbadensis gel on systemic suppression of delayed type cutaneous hypersensitivity (DTH)

Delayed type hypersensitivity (DTH) is another type of cell-mediated cutaneous immune response. It primarily involves the dermis although in severe reactions it can also involve the epidermis. It is generally directed against protein antigens such as alloantigen (Major histocompatibility complex (MHC) antigen) or infectious agents

Table 12.8 Crude A. barbadensis ARF Process A gel prevents systemic suppression of the DTH immune response by high dose (5,000 Joules/m2) UV radiation.

Percentage decrease from homologous control (Groups of five mice each)

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