Two different components were separated from Kidachi aloe which exhibited hypogly-caemic activity in spontaneously diabetic mice and normal mice. One component was separated from the succulent layer of the leaf (leaf pulp). This component decreased the blood glucose level by the IP and per os (by mouth) routes, and maintained the lower level for about 24 hours. On the other hand, administration of the superficial layer of the leaf skin to streptozotocin (pancreatic islets P-cells toxin)-induced diabetic mice significantly depressed hyperglycaemia and examination of the tissue section under the light microscope revealed less denaturation and necrosis of islets P-cells. These results indicate that Kidachi aloe relieves the diabetic condition by direct hypoglyceration and activates P-cells (Beppu etal, 1993).
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